In 2008 I took my Ruger #1 in 458 Lott to hunt Cape Buffalo in Zim. Worked a treat. Buf really didn't know that I only had one shot. I had to take a quartering shot into the left hip with a solid. Dug the slug out in his brisket. He went about 50 yards.

Hell, yes, take one. The knowledge of only one shot improves one's concentration remarkably.