If you are accompanied by a PH with a good back up rifle you can take what you want !

If you are alone only with a guide and trackers the situation is a little bit different . "Close encounters of the third kind" cannot be ruled out ! I mean lion's , elefants , hippos ... The case is rare , but a single shot rifle is imho not suitable for this situations ! The time of the safaris with a lot of gun bearers behind you is finish !