I packed a .458 2" for years. 400gr. @ 2,150fps, 350's at 2,296fps or 500's as 2,060fps as I hunted moose in grizzly country. Never saw a grizzly while hunting, yet when out looking for fire starter (paper birch bark) trees, in one morning, I saw 6. Go figure. LOL 2 of those were 1st year cubs, with momma. I was packing my .458 Alaskan that day, didn't have to use it. 400gr. @ 2,400fps.
Go figure.
Now, when I go out into the bush, I pack the '06, or more likely, a 12 bore rifle.