Ok guys, I'm rather new to the DR world having bought my .500 Merkel midway through last year.

I know that each gun is different, and I was wondering (will take all the laughs now if this is a moronic question) but has anyone ever had to use one load for one barrel and a different load for the other?

(I know that depending on the game you are hunting, you may have a solid in one and a soft in the other barrel, but when shooting say two solids, have you ever found that your rifle regulates with a different mix [different amount of powder or different type of powder] in each barrel?)

Again, sorry if this is moronic, but I am just curious.