if you want to talk american 45s and hunting... there are several reasonable cartridges out there... for instance, the 45-75, which while short lived, was designed to affect a one-shot Bison kill at 400 yards. we had one (1876 win) and sold it for something in the neighborhood of 10-grand IIRC.

then there are the 45 mags, the 45-90 and the 45-120, both would be considered potent enough for buff, but their rarity and the rifles they are typically built in are not exactly up to "buff" standards. if the 45-70 has ANY chance at being considered DG gun it is as a method of throwing a lot of soft-points at big cats in a very short time frame and at closing distances. even then, the BIG bullets desired in such a circumstance are not normally used in the 45-70, at least I don'r remember seeing them loaded that way...

what's the MV and ME on a 45-70 vs. a 375H&H anyway???