Not to create a fuss but the 416 shooting 400's at 2400 runs at much higher pressures than the 375H&H shooting 300's at 2500fps.

The 416 runs about 58,000 to 61,000psi with the above loads and that is ultramag territory.I only get about 3-4 loadings out of the ultras before using new brass.

I would think that the 375 H&H has a much greater safety margin at around 50,000 psi with the 300's for not disabling the gun in a bad situation.

This is the exact reason I bought a 416 Rigby for Africa.Lower pressures for the same velocities. My buddie was hunting lion last year in 113 degree weather. What if the bolt gun locks up and the animal charges? I want no chance for screwups.

I would not run a 458 Wm at max pressure for better velocity either. Better to have a 458 Lott and download it abit.Could you get away with higher pressures?? Probably but I would rather be safe.I doubt any animal shot would know the difference.