I caliber .416 and bullet weight 400gr and up, a good quality soft like Swift Aframe, Barnes, Rhino, TBBC are all that is needed. In .375 and 9.3, I would try and avoid the shoulderbone. However, if the buff is standing angled enough so that you can slip a bullet in front of the shoulder joint, that must rate as one of the best shots with even lighter (.375 class) to down a buff quickly.