Shoot what you can shoot accurately, even if its a .375.
I have seen plenty of missed brain shots with calibers up to .577 and .600 NE express that failed to drop elephant. I always thought that it is the margin that you miss the brain by that stunns or drops a non brain shot elephant, not the caliber that was used. Saying that, I will take on any charging elephant a .375 that I know well with complete confidance, as on elephant specifically, I think shot placement is the deciding factor. (also on the cats). On buffalo however, where I believe your shot options are more limited in a charge, I would like something bigger in a charge, but am 100% comfortable with a hunter/ client taking the first shot with a .375 class cartridge. On a recent buffalo hunt, a father and son shot these 2 buffalo with 3 shots from my 9,3x64. The 3rd shot was probaply not needed, the father gave it to the departing buffalo, on the left shoulder, we recovered the solid close to the right hip.