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Regarding dangerous game, 4000-5000 Ft/Lbs with .375-.500" projectile has proven to be a good killer. How about stopping a charge? Is a .500 or .577 nitro class necessary or just insurance?

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Very difficult to respond to your question, i deleted two times my reply ! We are again by the question or the fact : It's better to use big bores on big game or are medium bores sufficent for this job ?