To me, the two softer rounds are the 375 H&H and the 458 WinMag, one good shove. When you go up in the energy level like the 416 and above, it comes back at you a bit faster. They all are manageable if you have the right frame of mind when you light them off. The toughest to sight in on the bench has been 458 Lott but I was lucky to get it done under 10 rounds with my QD mounts and scope. Most of the big boys should be shot off hand anyways.