All the answers are good. The 375 is the most soft shooting of the bunch, whether the original H&H or otherwise. But, if you're really into "stopping" power, then going up the 416 in whatever flavor will be the obvious choice. You can split the difference by loading a 350 grain bullet and have a flat enough trajectory with a heavy enough bullet for stopping any critter up there.
-------------------- Lo do they call to me,
They bid me take my place among
them in the Halls of Valhalla,
Where the brave may live forever.
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