In reply to:

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The biggest disadvantage to the O/U is it gets top heavy as it gets bigger, and is a real bitch to get a shell chambered into that bottom chamber when running...at or away!! They have to be opened up sooo darned far, unlike a SXS. A 375 is about as big as I think is practicle in an O/U.

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The top heavyness depends much on what depth and style of action is used, what type of stock and forend is used, and also if a scope is fitted.

Big O/U doubles don't have to be top heavy.
I've handled a trim little open sighted O/U in 500 Nitro which had no top heavyness at all and ballanced beautifully.
Kicked well though!

If you are having trouble loading the bottom chamber while running perhaps you should try a different loading technique.
I don't find the O/U style any slower or harder than SxS to load the chambers.

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