I never understood the reasoning behind the .375 Flanged Magnum. Obviously, it's pressure is reduced because of that issue way back when. But the .375 H&H is widely available in doubles now.
It is too bad no one ever developed a full power .375 flanged, maybe a .375 Flanged SUPER Magnum. Just use a bigger case to reduce the pressure.
The 500/416 is a good idea, if it was only avaialble in stock rifles other than the Kreighoff!
But a .375 H&H at 100 yards is probably close to a .375 Flanged Magnum at the muzzle, so just use the Flanged at point blank range.
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Bill Stewart
Once you have been amongst them, there is no such thing as too much gun.