I just checked my load data versus your after reading SAHUNT's post where he mentions "I like my bullets not to fast. I believe you get better terninal balistics at a lower speed." which I totally agree with. Velocity doens't kill game.
Back off your loads a fair bit and work up as SA HUNT says.
I think you are going WAY too fast for some of those bullets and this is proably affecting accuracy.
Try 75 - 76 grains of ADI 2209 with 300gn bullet and work up Try 68 grains of ADI 2209 with 350gn bullet. I have loaded up to 74gns of 2209 for mv of 2375. You can probably go higher but why ? Long, Heavy for calibre bullet that kills well at 2375.
Max OAL is 3.6 on a 375H&H - stick just below that and don't change too many things at once when reloading and testing otherwise you wo't know what is causing the change.