I would start with a moderately priced quality SXS DR in 9,3X74R. The ammo is readily available and far less expensive than the heavy NE ammo. You can find excellent guns in the $5,000.00 to $6,000.00 range, and a SXS of quality will mever depreciate if properly cared for.
9,3X74R will handle anything in Alaska and almost everything in Africa. It is flexible and deadley. If you reload, you can shoot it for less than a buck a round. The 9,3X74R is my favorite round...it is low pressure, accurate with proper bullets, deadley, ecomonical, available, has moderate recoil, and is a Classic. Chapuis and Merkel make very nice moderately priced SXS DRs in this caliber.