"Hornady's reloading manual lists A-1680 with the 220 gr FP with the max charge listed at 41.2gr and 2300 FPS out of a Winchester "Big Bore 94" with a 20" barrel. DP"
I tried this load in my .375 Win. and it delivered lousy accuracy.
This is not to say, that at some level, it might shoot - I merely went back to what worked well and that was H335 and the 220gr.FN Hornady, a bullet designed specifically for the round. Here's a page of links with more pages listed under it.
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Re: .Reloading 0ptions for the .375 Winchester (bigbore)
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