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Must be very careful with light loads of Bullseye and most other pistol powders.
S&W, I have on excellent authority, has a room full of blown revolvers. Most are 357s blown with a 38 special full wadcutter charge of Bullseye in a 357 Mag case with a SWC bullet, too much air space. Few revolvers will survive 50 rounds of this.
Their own testing has shown that even a full case of bullseye will not blow the cylinder, just bulge it.
A friend blew a late prod. 1st gen SAA in 45 with 6.5 gr of Red Dot just by switching from a 250 to a 200 gr lead bullet. Nope 13 gr will not blow a SAA cylinder. He was talking to a senior employee at S&W about it saying he had probably put in 13 gr of powder. He was told this would not damage the cylinder. Testing the now top strapless revolver (remotely) with a different cylinder confirmed this. He said he knew something was a little "off" since he had a couple of squib loads before it blew. Meaning the powder was not igniting properly. But he was not attentive enough.

Loading cast bullets with IRM powders in rifle cases will do the same thing. Blows barrel and perhaps the action to fragments. 4831 in 7mm mags, 3031 in BPCRs that will shoot 50K psi with no problem. Blow up and fragment like grenades.

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