Yeah, I reckon they'd work pretty well on those big varmints! I think I might have been able to get 2800 with them in the 458 Win, but penetration on goats and pigs at 2700 was not too flash. I swaged a few 300's up to shoot in the 470, but had a couple of hangfires, and didn't shoot anymore of them after that. Also swaged up some 350 RN 458 Hornady's for the 470 and they work pretty well.