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you can duplicate that velocity (approx. 1,650fps) with a 420gr. bullet in the weaker actions, indeed, 1,700fps is available, with appropriate powders, of course.

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Gotcha.

And that load of 420/1700 is a very powerful load, no ifs ands or buts.

There are circumstances under which I'd take it over a .30-06. I'd rate, as Daryl says, my Lee cast Hollow Point 402 @ 1640 fps to be the equal of any .375 H&H Mag load at short range regardless of what bullet the .375 is using and the .45-70 maybe better.

I will not say my load is the equal of a .458 Mag or any other true big bore Nitro Express because I don't think it is, but the equal or better of the .375, yes, again, at close range.

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