Hey, Y'all,
Hey, partner, no need to apologize for anything said to me in reply. Having been a dumbass for the greater part of my 56 years, I've developed a fairly thick hide. Why, my wife reminds me of my limited mental capacity on a regular basis!!! Besides, I can come off rather salty myself sometimes.
Someone might have gotten the wrong impression of what I was getting to, because I would NEVER condone any load above the aforementioned factory pressure limit of 45,000 psi in a '95 lever action, new or old. My comments were strictly in reference to hot-rodding a really strong single-shot, such as the Ruger #1. If I misled, then please accept my apology.
One thing that might come into play with the necessarily longer 400 gr. bullet would be the amount of free-bore (or lack thereof) built into the Ruger chamber design. That would definitely be something to check out before assembling any loads with said bullet.

"When in Doubt, Use More Gun!!!"