Hey, Y'all
I've been hoping that someone would acquire either one of Ruger's #1s in .405, or one of the "Davidson" high wall Winnies, in that same caliber, and then play with it to find out just how good this old cartridge can be. I suspect that with a little development, a 400-gr. .411 solid could be shoved along at 2050-2100 fps. That would make Teddy Roosevelt's "big medicine gun" into real "big medicine"
Just about perfect, with a softie OR a solid for that pesky rhino or lion that keeps turning over your trash can every night, what? I've had no trouble at all in being able to move a Barnes 300-gr. at 2400 fps, and this from an early original '95.
Ken Waters did a great workup on this cartridge in Reloader Magazine some years back, wherein there are some super loads using Reloder-7 and several different bullets, and this is where I got my information for working up the 300 gr.-Re-7 load. He also had some loads for the 210-gr. Hornaday pistol bullet, again with a whole bunch of Reloder-7, at 2500-2600 fps, and I loaded a herd of these. Just let me tell ya, when this lightly-constructed hollow point, at 2600 fps, comes in contact with ANYTHING, it's Nagasaki time all over again. Loads of fun on 100-150-yard groundhogs.
I do believe that with the right propellant and primer, in a good, strong single shot, the 350-400 gr. 2100 fps figure is attainable.

"When in doubt, use more gun!!!"