260 Rem
You might want to reconsider.
For the last several years I have been using a 9,3x74R double rifle [a Chapuis]. I have hunted with it in Texas, Montana, Idaho, Canada, and two Safaris to Zimbabwe. I have taken game from raccoon and bobcat to black bear, zebra, giraffe cape buff and elephant, with perfect results.

ANYTHING I could do with a 375 H&H I can do with a 9,3x74R.

The 9,3 has become one of my favorite calibres.

Several years ago I bought my wife a Sauer Drilling in 12x12x30-06 with a 4x Kahles in claw mounts.
I have snuck it out sevedral times my self and found it to be a great hunting gun.

I think a 12x12x9,3x74R drilling to be one of the best hunting guns on the Planet, and that is what I wanted.... However I discovered I could not take a 9,3 double and a 9,3 drilling through South Africa at the same time.

So, I found a Drilling just like my wifes a 12x12x30-06 Sauer. It is at Champlin Arms being fitted with a S&B 1-4 scope right now.

I found that her drilling is one of the best handling shotguns I have ever used. I like it much better than my 12 ga Browning Citori. Now I have one for myself.

As an American the 12x12x30-06 is certainly a premier choice for a drilling... However the 9,3x74R is one of the greatest hunting calibers there is.

You just could not beat a scoped drilling in 12x12x9,3x74R.