A local chap, friend of mine, shoots a Merkle O/U 16 X 7x65R. He uses 160gr. TSX to good advantage and cloverleafs - or under 3/4" with these at 100 meters off the bags with reasonable frequency. No damage to his rifle.
I think his speeds are in the 2,650 to 2,700fps range.
The scope is a Zeiss has, which for me are horrid (but interesting looking) amounts to pointed fence post thick posts.
I cannot shoot it that well - the post's and for me, lack of precision, seemed to defeat me when I tried it. I did, however land my 3 into a 1" group at 100 meters. Pete, however loves the reticle and shoots it as it had a 6-24X Varmint scope on it.