I used to be a #1 fanatic until I became a double fanatic. I have had: a 22-250, 25/06, 30/06, 300Wm, 375H&H and a 45-70. Ruger #1 means non dangerous, but maybe large (moose) game. I'd choose the .300Wm as it is the most versatile, in fact; the 200 grain bullent can be driven fast enough to match the 375 in energy. BTW, I still have a .375 - but it's in a double, I sold all my #1's to pay for the double