I took a Cape Buf in Zimbabwe in 2006 with a #1 in 458 Lott. The animal went 125 yards with two .45 holes through its heart. It was stone dead when the bullet hit. The bullet was a Hornady 500-gr. solid and I use it as a paperweight. I have had some surgery on my left shoulder so I had to part with the Lott. I now have a #1 in .375 H&H. I'd use it on anything.