Some time ago i read about a ferlach double in 500NE with spare barrels in 375H&H, when shooting the 375 the gun was so stiff to open that it was a real problem but it worked fine with the 500NE.

It seems that the high pressure and fast peak of the 375 did flex the action more then the slower 500, knowing that the face of the 500 (14,5mm) is much larger then the 375 (13mm) but its only about 25% larger but the pressure is about 70% lower. (ruffly calculated from a malfunction brain)

My point would be that if a action can stand the high pressure of a smaller cartridge it could well be that it will stand the force of a larger one.
Take a drill, it will snap at high speed but only get stuck at lower speed even if the gear will put more force into it.