The smaller bores begin to impress more & more as the recoil of the larger bores starts to "wear" on the old bones & what used to pass as muscle tissue.
I'm finding I like my old 6.5's & the '06 more and more. But then, I don't hunt grizzlies, coastal or interior, nor do I guide any more.
Then, it was a .458 2" for backup, more often than not, a Barnes 400gr. at 2,150fps, my "old" standby load of 51gr. IMR4198. I did
pack the 400gr. at 2,450fps for a couple years, in a different chambering.