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Oh yeah - great grizzly gun! A .22-250 with 26" bl. will do the same.
I had one with a 26" bl.(.220 Swift)that ran 4,030fps with 50gr. Sierras. It wasn't a super hot load, either. Shot well and shot a bunch of ground squirrels with it. Had to shoot slowly due to barrel heat - switched to a .17 Ack. Bee after that.
Much better for the rats.

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I still have one--It's a Cooper single shot with a Leupold VX-3 6-18 on it..incredibly accurate..have mainly used it for prairie dogs.. took it once along with 5 other rifles to a P-dog town a rancher wanted eradicated.. shot over 400 in a afternoon .. town was gone the following spring..

Have to say however, it would not be on my top 10 choices for griz..