Oh yeah - great grizzly gun! A .22-250 with 26" bl. will do the same.
I had one with a 26" bl.(.220 Swift)that ran 4,030fps with 50gr. Sierras. It wasn't a super hot load, either. Shot well and shot a bunch of ground squirrels with it. Had to shoot slowly due to barrel heat - switched to a .17 Ack. Bee after that.
Much better for the rats.