OK ladies and gents, here's a topic that I hope generates a lot of comment. What's your favorite caliber for most of your medium and large game in North America. By medium game, I referring to animals the size of Pronghorn and Southern Whitetail, and by large, critters like Mule Deer, Northern Whitetail, Elk, Moose, and Black & Grizzly Bear. I like the .280 Remington, and the 7mm Remington Mag.for the medium stuff. For the larger stuff, most situations would find me using my .300 Winchester Mag, but if I were after the really big bears, I'd opt for my 375 Ackley Improved.