Many years ago some hunting friends, 3 brothers, changed to the 243W from the 22-250s they had been using on chamois and red deer and stated the 243W was vastly superior to the 22cal cartridge. They did find however that the 87-95 grain bullet killed better than the 100gr. From memory I think they were using Sako 90 or 95gr bullets and it may just have been the bullet that gave better performance to whatever 100gr they had been using.
Another hunter I knew who spent years meat shooting in our Fiordland area, home of our Wapiti (elk in the USA) and big Wapiti/Red hybrids used a 243W. In later years as he took up guiding for chamois and tahr in our Alps he went over to the 30.06 which he said gave him greater surety of kills at longer ranges when he had to 'help' out the client get animals on the ground.

The 243W has been a very popular cartridge here in NZ but is now well over shadowed by the 7mm-08 and 6.5x55 both of which are among the most common cartridges seen on the range and in the field today.