I'm getting 2025fps with a Hornady 350gr SNRN, shoting to the sights of my 500/450 3-1/2" Magnum BPE Tolley.
That's with about seventy-six grains of Varget and a Federal 215 primer.

I haven't worked a load up for anything in the 270-325 grain range, but considering the rate of twist in those bores, I might have good luck with the lighter bullets too.

--Tinker