Of course modern sport hunting is different from what the old timers faced in Africa. Normally a muzzleloader hunter has a PH to back him up with a big game rifle if things get hairy. Most of the PH's I've talked to say that they can get a muzzleloader hunter to within 50 yards of a Cape and the big bore muzzleloaders should be effective at that range. I am planning on going back to Africa or Australia and going after a buffalo. I had decided that next time I was going to take restored open sight Mausers in 9.3X62 and .458 Win Mag but then a company asked if I wanted to test a Selous-vintage 4 Bore they are going to manufacture. How can any dedicated muzzleloader hunter pass on that? So, its going to be interesting to see how such a big gun will perform. Muzzleloading in Africa is capable of becoming very popular if vintage style guns become available but you'd still want that PH there to back you up.