Sure NitroX I have done it already.

As I said up above, I have two in the works right now.

I have never done a double in anything bigger then an 8 bore however.

Not that I couldn't or wouldn’t, but I have not been asked.

A double 4 bore would be a very heavy rifle, but a strong man could probably manage it.
I'd have to guess that weight would come in at about 25-26 pounds

A double 2 would be ......... hard to imagine. You'd better be VERY strong to manage one of them.