From my reading of old books, the biggest problem they had in the old days with nitrocellulose as a propellant was that it was very erosive. Now I can't say if modern additives would prevent the erosion of the bore, and also the use of better steels in the barrels, so perhaps it would not be the problem it once was.
But in the 1890s to the 1920s most nitro substitutes for black powder were failures for that reason. Guns that had a bore life of 20,000 rounds of black powder had a bore life of 1,000 with nitro, and some were washed out in as little as 400 rounds.
The additions of tin was a big step forward in this too. But I have no modern data on the subject
SZ