"All takedown arms with screw threads have the problem of thread wear"

When does "thread wear" become a problem?

When the rifle is new? After 1,000, 10,000 take downs, 20,000 takedowns, ???
Or is it age in decades? Or is it a physical fact that can be adjusted for as use and time passes?
One of my Winchester TD rifles has the ability to adjust for thread wear. After 20 years, no sign of wear yet.

Personally, I think too much fuss is made of takedown thread wear. Yes it could happen, but with how many takedowns? Until it happens OR the maker (Winchester) tells me when/how many takedowns, I will not lose any sleep over it. Therefore, thread wear is a possibility, but not a problem.
Those rifles will probably outlast me by a LONG time.