I used your load of H335 with the 232 Vulkans! Smacked a black bear and 3 deer quite smartly, too.
I just picked Norma factory load velocities as a goal. If I don't have any significant case expansion when I get to 2350 (Vulkans) and 2100 (PRVIs), I'll probably see where I can go with 4166. Hodgdon reloading data suggests 4166 curves up rather abruptly compared to 4895 and 4064 approaching MAX loads. So I'll bear that in mind as work up. Can't just plug in the 4064 data safely on the top end.
I could just buy Norma powders and be done, but that's no fun.