The 250 Spitzers and 280gr. RN's were each running in the 2,700fps range and both worked splendidly on coyotes. I was shooting from 50 to 150yards and lighter flatter shooting bullets were quite simply, not required. My other alternative (also used) was my .458 2" with 400gr. FN's & Spitzers at 2,150fps - again, out of 150yards, NP on coyotes.