Beautiful rifle.

.375 & .416 ?????? Not my pick of calibres (.300 H&H & .375 H&H or .300 Wby & .375 Wby) but then it's the client's choice as it's their money.

The case would be heavy but you'd only be lugging it around airports and then it'd be left in your tent/rondavel/chalet while you were carrying the rifle with one of the barrels/scopes mounted.