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Yes, there was a discussion as to whether or not they would be to hard for the 375NE 2 1/2 however as yours is the 2 1/4 rimless which is quite a bit faster they seem to work well. They also feed very nicely.

Matt.

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Above, 9.5 is the 9.5X57
Below, the MS is loaded with two more grains of Cordite than the RNE, Flanged Nitro - Express is the .375NE 2.5"