2450fps sounds pretty good for a max speed on the 235gn .375 Speer. Like the 9.3 270gn Speer, the .375 235 gn is pretty soft and won't like much more velocity than that.
I shot a few of these with full loads in an early peep sight Brno 602 .375 H&H, back in the early 1980's, and had extreme bullet failure with the bullets totally fragmenting on medium game.
At 375 H&H velocity they are too soft IMO, but should be fine at 2500 or less.