I use 45ACP with 230gr FMJ for finishers only (neck shots - must break vertebra - in/out clean wounds ~ 3/4 cal. dia) - for hunting .45ACP just gasps for velocity as 57 said - I'd limit myself for distances max. 25m with tad faster (P+ if it works in your gun) and lighter JHP on critters up to 80kg (broadside behind the shoulder shots). No point in comparing it with .44 Mag.