A 500 gr or more projectile would be very effective.

Ballistic performance
Bullet mass/type Velocity Energy
300 gr (19 g) FTX Hornady 2,075 ft/s (632 m/s) 2,868 ftlb (3,888 J)
350 gr (23 g) XTP HP Underwood 1,912 ft/s (583 m/s) 2,842 ftlb (3,853 J)
520 gr (34 g) WFNGC TII +L 1,580 ft/s (480 m/s) 2,882 ftlb (3,907 J)
620 gr (40 g) WFNGC TII +L 1,390 ft/s (420 m/s) 2,660 ftlb (3,610 J)
700 gr (45 g) WFN Underwood 1,200 ft/s (370 m/s) 2,238 ftlb (3,034 J)

Test barrel length: 8.375 in
Source(s): Hornady (300 gr),[1] Underwood,[2] and TII Armory (520 gr +L and 620 gr +L),[3]

https://en.m.wikipedia.org/wiki/.500_S%26W_Magnum