Daryl, I've shot it with 20grs of 3F and a roundball but I think 30grs is the max in the wedge frame guns, not sure.

I forgot that I also had a Colt reissue 36cal Navy (the one with the squared nickeled trigger guard and a 44 Army with the fluted cylinder.
The top two are the 36 Navy and the 44 Navy - you can see the 44 has a flare in the cylinder for the bigger holes.