From my experience the Colt 1911 and Browning Hi Power have the right grip angle for good point shooting. the grip angle on the Glock is the only negative thing about it from my perspective.

I have carried and instructed on Revolver, (Smith M10), and semi auto's, HK USP and Glock. I found for those who put the time into practice the revolver was more accurate but not as fast with follow up shots. Now I am talking about normal humans here not your gun nut type. Also with the heavier trigger pull the follow up shots with the revolver where off center. Practice rectified this.

For defence against two legged predators I prefer the semi-auto. The main reason is nowadays you are more likely to run into more than one aggressor at the time. Downside is those who only do the very basics so as to pass a qualification shoot my blaze away under stress, as might most people who are not trained and put under pressure during training.

Just remember most of the people I am talking about do not practice and do not put much thought into using their firearms.