We had a talk at the bench the other day about 475 Linebaugh vs 500 JRH
Similar bullet weight vs velocity.
I'm soon to start a conversion of a Redhawk to 5-shot big bore. My thought, from the logical standpoint that greater sectional density of the 475 bullet would/should get better penetration (given similarly constructed hard cast flat points) than the 500 bullet.

Jack agreed with the logic, and explained that in this case, the logic of sectional density being the winner at penetration wasn't necessarily the winner after all.
After many scores of large bovine taken with both cartridges, the 500 tends to outpenetrate the 475, if only by a little bit - this is when comparing similar bullet weight and velocity 475 vs 500

This is via handgun, on live game.