I'm on my 3rd one.

https://www.smith-wesson.com/firearms/model-29-sw-classics-4-blue

It think that Titanium 4" would belt (me) pretty bad with 300's.

In my 1st 4" S&W, I got the same poi using 26.0gr. 2400 and 180gr. JHC's and 22gr. 2400 and 275 SWC's. The 180's were for 2 legged and the others for vehicles, however I found the 180's were better for vehicular penetration as well as stopping quite quickly in gel.