Rattle snakes are a big problem in South Texas. I think last year was the first time a new vaccine was offered here. It consists of a 2 injection treatment. The 2nd shot administered 30 days after the first. I understand it to be very effective in reducing the effects of a bite. Had my Lab inoculated there were no side effects. Fortunately did not get a chance to test effectiveness.
Most upland hunters here also have dogs "snake broke" using live defanged snakes and shock collars. Here in Houston the
German Shorthair Club puts on an annual Desnaking Clinic"