Yes - with those light bullets it would have been used on all smaller big game originally. A 300gr. intermediate hardness cast HP at 1,700fps to 2,000fps also makes a decent intermediate sized moose round. My bro's .45 3 1/4" Sharps did a very good job on moose with a 300gr. jacketed bullet. 1" exit out the other side - double lung'd & dropped inside 40yards, a 50 yard shot. The moose wasn't big, about 500pounds.