Due to it's longer case and longer barrels, although held to lower pressures, the .375 2 1/2" pretty much duplicates the .375 Winchester, which is a 2" case, but run at up to 53,000psi.

They are wonderful ballistics guys - do not underestimate them. The two moose I shot with my wife's (now mine) .375 Winchester died in 1 1/2 and 4 steps respectively. That's faster than dozens of others I've seen shot with everything from 6.5's to .458's. It's also faster than any I've seen shot with 7mm and .300 mags. I'm not saying they are more powerful, just that in those instances, the little 'pokey' round killed faster.